1. crucial
A crucial question in the field of gene regulation is whether...
Chronic inflammation in fat plays a crucial role in the
has a crucial role in the
2. key
the following two key questions were identified
One of the key questions in climate change research relates to the future dynamics
3. critical
To resolve the critical question of accurate identification of the macrophages
When multiple outcomes are assessed, a critical question to be considered is whether
these should be examined separately or somehow integrated,
reveal a critical role in
4. essential
The essential problem here is to find a feasible path from a source
So this raises the essential questions
The essential questions are as follows
5. vital
6. pivotal
This question is pivotal to the business-case issue
7. extremely important
8. fundamental
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